The Specificity of Vesicle Trafficking: Coat Proteins and SNAREs
نویسندگان
چکیده
منابع مشابه
The specificity of vesicle trafficking: coat proteins and SNAREs.
Proteins that are destined for the secretory system usually begin their journey at the endoplasmic reticulum (ER), where proteins are translocated across the ER membrane into the lumen, before being selectively removed from the ER and packaged as cargo into transport vesicles bound for the stacks of the Golgi complex. Protein cargo then passes through the Golgi to the trans -Golgi network (TGN)...
متن کاملThe Sec34/Sec35p complex, a Ypt1p effector required for retrograde intra-Golgi trafficking, interacts with Golgi SNAREs and COPI vesicle coat proteins
The Sec34/35 complex was identified as one of the evolutionarily conserved protein complexes that regulates a cis-Golgi step in intracellular vesicular transport. We have identified three new proteins that associate with Sec35p and Sec34p in yeast cytosol. Mutations in these Sec34/35 complex subunits result in defects in basic Golgi functions, including glycosylation of secretory proteins, prot...
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p115 SNAREs a vesicle protein known to tether vesicles during intra-Golgi trafficking also ensures their correct docking, according to new results from Shorter et al. (page 45). This provides the first link between the long-range process of tethering and the short-range process of docking. Vesicle transfer consists of four successive reactions: vesicle formation, tethering, docking, and fusion....
متن کاملMolecular structures of proteins involved in vesicle coat formation.
This review includes 16 structures of vesicle coat components and accessory proteins and a description of their roles in vesicle budding or coat disassembly.
متن کاملCommentary SNAREs and regulated vesicle exocytosis
Synaptic vesicle exocytosis—the basis for neurotransmitter release at nerve terminals—is at the heart of nervous system functioning. The molecular analysis of this special form of exocytosis was recently greatly stimulated by the finding that the key molecules in various intracellular vesicular transport steps, including neurotransmitter release, are conserved from yeast to man (1–3). Prompted ...
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ژورنال
عنوان ژورنال: The Plant Cell
سال: 1999
ISSN: 1040-4651,1532-298X
DOI: 10.1105/tpc.11.4.629